Agrin



Agrin (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors. Its N-terminal domain NtA binds laminin. The C-terminal of Agr has 3 laminin binding domains (LMB): G1-G3. The images at the left and at the right correspond to one representative Agrin, i.e. the crystal structure of chicken Agrin (3i70).

3D Structures of Agrin
3i70, 1pxu – cNtA – chicken

1pz7, 1pz8, 1pz9 – cAgr

1q56 – cAgr-G3+Ca – NMR

1jb3, 1jc7 – cAgr LMB

3pve – Agr G2 - mouse